PharMerica has been selected as a Long-Term Care Pharmacy Provider for KYNMOBI® (apomorphine HCl) sublingual film.
KYNMOBI® (apomorphine HCl) is a prescription medicine used to treat short-term (acute), intermittent “off” episodes in people with Parkinson’s disease (PD).¹
The most common side effects of KYNMOBI include nausea, sleepiness, dizziness, and mouth swelling, pain, or sores. Please see Important Safety Information below.
What is the difference between ON vs. OFF time?
- ON time is when your Parkinson’s disease symptoms are improved by your oral levodopa.
- OFF time is when your symptoms come back or reappear.
For which types of OFF times can KYNMOBI be used?
KYNMOBI is the first and only sublingual (under the tongue) treatment for OFF times in PD, including:¹
- Morning OFF: Occurs when you wake up OFF because your last dose of levodopa has worn off. Additionally, after you take your first dose of levodopa, you experience an OFF time until that dose takes effect (delayed ON)
- Wearing OFF and Delayed ON: You may experience OFF times during the afternoon and the evening that occur when your levodopa wears OFF (wearing OFF) or a new dose takes longer to take effect (delayed ON)
- Unpredictable/Unexpected OFF: You may have other OFF times throughout the day that happen suddenly without any warning and are not necessarily related to the timing of your levodopa doses
- Do not take more than 1 dose of KYNMOBI every 2 hours.
- Do not take more than 5 doses of KYNMOBI each day (and no more than 1 film per OFF time).
IMPORTANT SAFETY INFORMATION AND INDICATION FOR KYNMOBI (apomorphine hydrochloride) SUBLINGUAL FILM
Do not take KYNMOBI if you are taking certain medicines to treat nausea called 5HT3 antagonists, including ondansetron, granisetron, dolasetron, palonosetron, and alosetron. People taking ondansetron together with apomorphine, the active ingredient in KYNMOBI, have had very low blood pressure and lost consciousness or “blacked out.”
Do not use KYNMOBI if you are allergic to apomorphine hydrochloride or to any of the ingredients in KYNMOBI. KYNMOBI also contains a sulfite called sodium metabisulfite. Sulfites can cause severe, life‐threatening allergic reactions in some people. An allergy to sulfites is not the same as an allergy to sulfa. People with asthma are more likely to be allergic to sulfites. Call your healthcare provider if you have hives, itching, rash, swelling of the lips, tongue and mouth, redness of your face (flushing), throat tightness, trouble breathing or swallowing.
Before starting KYNMOBI, tell your healthcare provider:
About all of your medical conditions, including if you:
- have difficulty staying awake during the daytime
- have liver problems
- have dizziness
- have kidney problems
- have fainting spells
- have heart problems
- have low blood pressure
- have had a stroke or other brain problems
- have asthma
- have a mental problem called a major psychotic disorder
- are allergic to any medicines containing sulfites
- drink alcohol
- are pregnant or plan to become pregnant. It is not known if KYNMOBI will harm your unborn baby
- are breastfeeding or plan to breastfeed. It is not known if KYNMOBI passes into your breast milk. You and your healthcare provider should decide if you will take KYNMOBI or breastfeed.
Tell your healthcare provider about all the medicines you take, including:
- prescription medicines
- over-the-counter medicines
- herbal supplements
KYNMOBI may affect the way other medicines work, and other medicines can affect how KYNMOBI works. Taking KYNMOBI with other medicines may cause serious side effects. If you take nitroglycerin under your tongue (sublingual) while using KYNMOBI, your blood pressure may decrease and cause dizziness. You should lie down before and after taking sublingual nitroglycerin.
KYNMOBI can cause serious side effects, including:
- Nausea And Vomiting. Nausea is a common side effect of KYNMOBI. Nausea and vomiting can happen with KYNMOBI. Your healthcare provider may prescribe a medicine called an antiemetic, such as trimethobenzamide to help prevent nausea and vomiting. If trimethobenzamide is prescribed, talk to your healthcare provider about how long you should remain on this medicine.
- Sleepiness Or Falling Asleep During The Day. Sleepiness is a serious, and common side effect of KYNMOBI. Some people treated with KYNMOBI may get sleepy during the day or fall asleep without warning while doing everyday activities such as talking, eating, or driving a car.
- Dizziness. Dizziness is a serious, and common side effect of KYNMOBI. KYNMOBI may lower blood pressure and cause dizziness. Dizziness can happen when KYNMOBI treatment is started or when the KYNMOBI dose is increased. Do not get up too fast from sitting or after lying down, especially if you have been sitting or lying down for a long period of time.
- Mouth (Oral) Irritation. Mouth (oral) irritation is a common side effect of KYNMOBI. You should call your healthcare provider if you develop any of these signs or symptoms.
- mouth sores (ulceration)
- dryness of the mouth, lips or tongue
- pain with swallowing
- Falls. The changes that can happen with PD, and the effects of some PD medicines, can increase the risk of falling. KYNMOBI may also increase your risk of falling.
- Hallucinations Or Psychotic-Like Behavior. KYNMOBI may cause or make psychotic-like behavior worse including hallucinations (seeing or hearing things that are not real), confusion, excessive suspicion, aggressive behavior, agitation, delusional beliefs (believing things that are not real), and disorganized thinking.
- Strong (Intense) Urges. Some people with PD have reported new or strong uncontrollable urges to gamble, increased sexual urges, increased urges to spend money (compulsive shopping), and other intense urges, while taking PD medicines, including KYNMOBI. If you or your family members notice that you have strong urges, talk to your healthcare provider. The strong urges may go away if your KYNMOBI dose is lowered or stopped.
- High Fever And Confusion. KYNMOBI may cause a problem that can happen in people who suddenly lower their dose, stop using, or change their dose of KYNMOBI. Symptoms include:
- very high fever
- stiff muscles
- changes in breathing and heartbeat
- Heart Problems. If you have shortness of breath, fast heartbeat, chest pain, or feel like you are going to pass out (faint) while taking KYNMOBI, call your healthcare provider or get emergency help right away.
- Tissue Changes (fibrotic complications). Some people have had changes in the tissues of their pelvis, lungs, and heart valves when taking medicines called nonergot derived dopamine agonists like KYNMOBI.
- Prolonged Painful Erections (priapism). KYNMOBI may cause prolonged, painful erections in some people. If you have a prolonged and painful erection, you should call your healthcare provider or go to the nearest hospital emergency room right away.
The most common side effects of KYNMOBI include:
- mouth swelling, pain, or sores
KYNMOBI® (apomorphine HCl) sublingual film is a prescription medicine used to treat short-term (acute), intermittent “off” episodes in people with Parkinson’s disease (PD).
For more information, please see the KYNMOBI Patient Information, full Prescribing Information, and Instructions for Use.
If your facility is presently treating residents diagnosed with Parkinson’s disease and their physician would like to prescribe KYNMOBI, please contact PharMerica and we will coordinate the next steps, including insurance coordination and medication delivery. Phone: 1-800-678-7575 | Fax: 1-866-470-1341
All trademarks are the property of their respective owners.
1. KYNMOBI (apomorphine hydrochloride) [Prescribing Information]. Sunovion Pharmaceuticals Inc., Marlborough, MA. August 2021.
Contact us today to start a new partnership in delivering superior care.